:root{--background:#f4f7f6;--surface:#fff;--surface-subtle:#f8faf9;--ink:#17211f;--muted:#61706c;--border:#d9e1de;--border-strong:#bcc9c5;--brand:#126f69;--brand-dark:#0d514d;--brand-soft:#e6f3f1;--green:#26724a;--green-soft:#e7f4ec;--red:#b5463e;--red-soft:#faece9;--amber:#8a661a;--amber-soft:#fbf3df;--focus:#16837c;--shadow:0 10px 28px #18302b14}*{box-sizing:border-box}html,body{min-height:100%}body{background:var(--background);color:var(--ink);margin:0;font-family:Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,sans-serif}button,input,textarea{font:inherit}button{cursor:pointer}button:disabled{cursor:not-allowed;opacity:.58}h1,h2,h3,p{margin-top:0}h1{letter-spacing:0;margin-bottom:0;font-size:3rem;line-height:1.05}h2{letter-spacing:0;margin-bottom:0;font-size:1.18rem;line-height:1.3}h3{letter-spacing:0;margin-bottom:8px;font-size:1rem;line-height:1.35}.appShell{width:min(1180px,100% - 32px);margin:0 auto;padding:28px 0 36px}.appHeader{max-width:840px;margin-bottom:24px;padding:10px 0 6px}.brandLine{align-items:center;gap:10px;margin-bottom:18px;display:flex}.brandMark{background:var(--brand-dark);color:#fff;border-radius:8px;justify-content:center;align-items:center;width:42px;height:42px;display:inline-flex}.eyebrow,.sectionEyebrow{color:var(--brand-dark);letter-spacing:0;text-transform:uppercase;margin:0 0 5px;font-size:.76rem;font-weight:800}.brandLine .eyebrow{margin-bottom:0}.subtitle{color:#31423e;margin:14px 0 0;font-size:1.25rem;font-weight:700;line-height:1.45}.heroDescription{max-width:680px;color:var(--muted);margin:8px 0 0;font-size:1rem;line-height:1.6}.statusPanel{border:1px solid var(--border);color:var(--brand-dark);background:#ffffffb3;border-radius:8px;align-items:flex-start;gap:11px;margin-bottom:18px;padding:12px 14px;display:flex}.statusPanel div{gap:2px;display:grid}.statusPanel strong{font-size:.92rem}.statusPanel span{color:var(--muted);font-size:.84rem;font-weight:650}.statusWarning{color:var(--red)!important}.workspace{grid-template-columns:minmax(0,1fr) 320px;align-items:start;gap:20px;display:grid}.mainColumn{gap:20px;display:grid}.toolPanel,.resultPanel,.historyPanel{border:1px solid var(--border);background:var(--surface);box-shadow:var(--shadow);border-radius:8px}.toolPanel,.resultPanel{padding:24px}.historyPanel{padding:18px;position:sticky;top:20px}.panelHeader{justify-content:space-between;align-items:center;gap:14px;margin-bottom:20px;display:flex}.buildPill,.resultStatus{background:var(--brand-soft);min-height:28px;color:var(--brand-dark);white-space:nowrap;border:1px solid #9fc9c5;border-radius:999px;align-items:center;gap:6px;padding:4px 10px;font-size:.76rem;font-weight:800;display:inline-flex}.formGrid{grid-template-columns:repeat(2,minmax(0,1fr));gap:14px;display:grid}label{color:#465652;gap:7px;font-size:.86rem;font-weight:750;display:grid}input,textarea{border:1px solid var(--border-strong);width:100%;color:var(--ink);background:#fff;border-radius:8px;outline:none;transition:border-color .14s,box-shadow .14s}input{min-height:44px;padding:0 12px}textarea{resize:vertical;min-height:118px;padding:12px;font-family:SFMono-Regular,Consolas,Liberation Mono,monospace;line-height:1.5}input::placeholder,textarea::placeholder{color:#899591}input:focus,textarea:focus{border-color:var(--focus);box-shadow:0 0 0 3px #16837c24}.sequenceField{margin-top:16px}.notesField{margin-top:14px}.fieldHelp{color:var(--muted);justify-content:space-between;gap:12px;margin-top:8px;font-size:.82rem;font-weight:650;display:flex}.buttonRow{flex-wrap:wrap;gap:10px;margin-top:20px;display:flex}.primaryButton,.secondaryButton,.iconButton{border-radius:8px;justify-content:center;align-items:center;font-weight:800;transition:background .14s,border-color .14s,color .14s;display:inline-flex}.primaryButton,.secondaryButton{gap:8px;min-height:44px;padding:0 17px}.primaryButton{border:1px solid var(--brand-dark);background:var(--brand);color:#fff}.primaryButton:hover:not(:disabled){background:var(--brand-dark)}.secondaryButton,.iconButton{border:1px solid var(--border);background:var(--surface-subtle);color:var(--ink)}.secondaryButton:hover:not(:disabled),.iconButton:hover:not(:disabled){border-color:var(--border-strong);background:#edf2f0}.iconButton{width:38px;height:38px;padding:0}.resultPanel{min-height:180px}.statePanel,.errorPanel{align-items:center;gap:14px;display:flex}.statePanel{color:var(--muted)}.statePanel h2,.errorPanel h2{margin-bottom:4px}.statePanel p,.errorPanel p{margin-bottom:0;line-height:1.5}.stateIcon{background:var(--brand-soft);width:46px;height:46px;color:var(--brand-dark);border-radius:8px;flex:none;justify-content:center;align-items:center;display:inline-flex}.loadingState .stateIcon{background:#eef3f2}.errorPanel{color:var(--red);background:snow;border-color:#b5463e57}.errorPanel p{color:#75453f}.resultComplete{border-top:3px solid var(--brand)}.resultComplete.pathogenic{border-top-color:var(--red)}.resultComplete.benign{border-top-color:var(--green)}.resultHeader{margin-bottom:16px}.assessmentSummary{border-top:1px solid var(--border);border-bottom:1px solid var(--border);justify-content:space-between;align-items:flex-start;gap:20px;padding:22px 0;display:flex}.assessmentLabel{color:var(--muted);text-transform:uppercase;margin-bottom:7px;font-size:.78rem;font-weight:800;display:block}.assessmentSummary h3{margin-bottom:0;font-size:1.35rem}.assessmentContext{color:var(--muted);margin:7px 0 0;font-size:.9rem;font-weight:650}.riskBadge{white-space:nowrap;border-radius:999px;align-items:center;min-height:34px;padding:7px 12px;font-size:.84rem;font-weight:850;display:inline-flex}.riskBadge.pathogenic{background:var(--red-soft);color:var(--red)}.riskBadge.benign{background:var(--green-soft);color:var(--green)}.probabilityGrid{grid-template-columns:repeat(2,minmax(0,1fr));gap:22px;padding:22px 0 4px;display:grid}.probabilityHeading{color:#455550;justify-content:space-between;align-items:baseline;gap:12px;margin-bottom:9px;font-size:.88rem;font-weight:750;display:flex}.probabilityHeading strong{color:var(--ink);font-size:1.08rem}.probabilityTrack{background:#e6ecea;border-radius:999px;width:100%;height:9px;overflow:hidden}.probabilityFill{border-radius:inherit;height:100%}.probabilityFill.pathogenic{background:var(--red)}.probabilityFill.benign{background:var(--green)}.confidenceSummary{border-left:3px solid var(--brand);color:var(--brand-dark);align-items:center;gap:11px;margin-top:20px;padding:8px 0 8px 13px;display:flex}.confidenceSummary div{gap:2px;display:grid}.confidenceSummary span{color:var(--muted);font-size:.78rem;font-weight:700}.confidenceSummary strong{font-size:.94rem}.interpretationSection{border-top:1px solid var(--border);margin-top:24px;padding-top:22px}.interpretationSection p,.recommendationBlock p{color:#40504c;margin-bottom:0;line-height:1.65}.recommendationBlock{border-left:3px solid var(--amber);color:var(--amber);align-items:flex-start;gap:12px;margin-top:20px;padding:12px 0 12px 14px;display:flex}.recommendationBlock svg{flex:none;margin-top:1px}.recommendationBlock h3{color:var(--ink)}.technicalDetails,.noticeDetails{border-top:1px solid var(--border);margin-top:22px;padding-top:14px}.technicalDetails summary,.noticeDetails summary{cursor:pointer;color:#41514d;justify-content:space-between;align-items:center;gap:12px;font-size:.9rem;font-weight:800;list-style:none;display:flex}.technicalDetails summary::-webkit-details-marker{display:none}.noticeDetails summary::-webkit-details-marker{display:none}.technicalDetails summary span{align-items:center;gap:8px;display:inline-flex}.detailsChevron{transition:transform .16s}.technicalDetails[open] .detailsChevron{transform:rotate(180deg)}.technicalGrid{border-top:1px solid var(--border);grid-template-columns:repeat(2,minmax(0,1fr));gap:0 24px;margin:16px 0 0;display:grid}.technicalGrid div{border-bottom:1px solid var(--border);grid-template-columns:minmax(120px,.8fr) minmax(0,1.2fr);gap:12px;padding:11px 0;display:grid}dt{color:var(--muted);text-transform:uppercase;font-size:.76rem;font-weight:800}dd{overflow-wrap:anywhere;color:var(--ink);text-align:right;margin:0;font-size:.86rem;font-weight:750}.emptyHistory{color:var(--muted);margin-bottom:0;font-size:.9rem;line-height:1.5}.historyList{gap:9px;display:grid}.historyItem{border:1px solid var(--border);width:100%;min-height:72px;color:var(--ink);text-align:left;background:#fff;border-radius:8px;gap:5px;padding:12px;display:grid}.historyItem:hover{background:var(--surface-subtle);border-color:#8ab7b2}.historyItem.selected{border-color:var(--brand);box-shadow:0 0 0 2px #126f691f}.historyVariant{overflow-wrap:anywhere;font-weight:850}.historyMeta{color:var(--muted);text-transform:capitalize;font-size:.81rem;font-weight:700}.historySequence{color:#74817d;overflow-wrap:anywhere;font-family:SFMono-Regular,Consolas,Liberation Mono,monospace;font-size:.74rem}.appFooter{border-top:1px solid var(--border);color:var(--muted);margin-top:28px;padding:20px 2px 0;font-size:.84rem;line-height:1.55}.appFooter>p{max-width:920px;margin:7px 0 0}.noticeHeading{color:#465652;align-items:center;gap:8px;display:flex}.noticeDetails{max-width:920px;margin-top:12px;padding-top:10px}.noticeDetails ul{margin:12px 0 0;padding-left:20px}.noticeDetails li+li{margin-top:5px}.spin{animation:.8s linear infinite spin}@keyframes spin{0%{transform:rotate(0)}to{transform:rotate(360deg)}}@media (max-width:980px){.workspace{grid-template-columns:1fr}.historyPanel{position:static}}@media (max-width:680px){h1{font-size:2.3rem}.subtitle{font-size:1.08rem}.appShell{width:min(100% - 20px,1180px);padding:18px 0 28px}.toolPanel,.resultPanel,.historyPanel{padding:17px}.formGrid,.probabilityGrid,.technicalGrid{grid-template-columns:1fr}.assessmentSummary{flex-direction:column;align-items:flex-start;gap:14px}.technicalGrid div{grid-template-columns:1fr;gap:4px}.technicalGrid dd{text-align:left}.fieldHelp,.buttonRow{display:grid}.primaryButton,.secondaryButton{width:100%}}